Biography
Minnie M. Sarwal M.D., Ph.D., FRCP, DCH is Professor in Residence, Department of Surgery, Division of Transplant Surgery, Co-Director of the Pancreas Kidney Transplant Program, Director of the Precision Transplant Medicine, Sarwal Lab at UCSF. Sarwal is a nationally and internationally recognized leader in the fields of renal and transplant medicine, genomics, proteomics and immunology. The Sarwal Lab supported precision and predictive diagnostic and therapeutic approaches for organ transplant recipients by discovering new treatments and investigative approaches using in vitro, CRISPR-Cas9, and animal KO models relevant to kidney disease, FSGS and transplant rejection. Sarwal was Professor of Surgery, Pediatrics and Immunology at Stanford University, Medical Director of the Pediatric Kidney Transplant Program at Lucille Packard Children's Hospital and Director of the Sarwal Lab for 16 years prior to joining UCSF in 2014.
Sarwal received her M.D. from Calcutta Medical College in India, completed her residency in the UK, and a fellowship in Pediatric Nephrology at Guy's Hospital, London, UK. She earned her Ph.D. in Molecular Genetics from Cambridge University (Christ's College) where she worked with Nobel Laureate Sydney Brenner on the synthetic mapping of human and puffer fish G proteins. Sarwal also holds a Diploma in Child Health from London, UK, and degrees from the Royal College of Physicians, UK (MRCP) and is an elected Fellow of the Royal College of Physicians, UK in recognition of her outstanding contributions to the field of medicine. Sarwal is a member of numerous national and international societies including the ASN, IPTA, AST, TTS, and IPNA. She is Chief Editor, Frontiers in Nephrology (a nature journal), AE for Clinical Transplantation and has published in and served as AE/reviewer for many other scientific journals inclusive of the Nature Medicine, NEJM, AJT, Nature Communications, PNAS, Journal of Immunology and Journal of Experimental Medicine.
Sarwal has also been the recipient of numerous awards and distinctions, including the Order of Excellence in Scientific Research (Cambridge, UK, 2002), the Dean's Teaching Award (2005), the Junior Faculty Award from the CCIS (2003-6), recognized Key Opinion Leader in Organ Transplantation by the Transplantation Society (2007-2009), elected Senator at Large for the Stanford Faculty Senate (2005-10), Faculty Senate UCSF (2015-17), the TTS-Roche Award for Outstanding Achievement Transplantation Science (Clinical; 2010), and the Cunio Richardson NKF Award for Scientific Excellence (2012). She also serves on the FDA Science Board for her third term, and is current Chair of the NIH-SBIR review study section and is Chair of the Department of Defense, Tissue Transplantation section. She is also a successful entrepreneur scientist and a founding member of the Rosenman Institute at UCSF.
Videos
Education
La Martiniere, Calcutta, India, English Language and Literature, I.S.C.,1981
Calcutta Medical College, Calcutta, India, M.D.,1985
Diploma in Child Health (D.C.H.), London, UK, with distinction 1989
Cambridge University, U.K, Ph.D.,1995
Residency (Medicine and Surgery), Calcutta Medical College, India, 06/1986-06/1987
Senior House Officer (Pediatrics and Surgery), Calcutta Medical College, India. Advisors: Sir Keith Peters, Sir Cyril Chantler and Sydney Brenner, 06/1987-02/1988
Senior House Officer, General Pediatrics & Neonates, Good Hope Hospital, Sutton Coldfield, Birmingham, UK, 02/-07/1989
Senior House Officer, General Pediatrics & Neonates, Grantham and Kesteven Hospital, Granthan (GKGH), UK, 03/1988-02/1989
Senior House Officer, Neonatology, Leicester Royal Infirmary (LRI), Leicester, UK, 08/-11/1989
Senior House Officer, General Pediatrics & Neonates, Leicester General Hosp. (LGH), Leicester, UK, 12/89- 03/90
Registrar, Pediatric Cardiology and Cardiothoracic Surgical Unit, Groby Road Hospital, (GRH), Leicester, UK, 04/90-07/90
Senior House Officer, Pediatric Nephrology Unit, Guy's Hospital, London, UK, 08/90-10/90
Lecturer/Registrar, Pediatric Unit, Guy's Hospital, London, UK, 10/90-09/91
Lecturer/Senior Registrar, Pediatric Nephrology, Dept. of Pediatrics, Guy's Hospital, London, U.K., 10/92-07/95
Fellowship in Nephrology, Department of Pediatrics, Addenbrooke's Hospital, Cambridge, 10/91-09/92
Ph.D., Molecular Genetics Unit, Christs College, Cambridge University, 10/92-12/95
Clinical Expertise
Acute Kidney Failure
Chronic Kidney Disease
End-Stage Renal Disease
Kidney Transplant Clinical Trials
Pediatric Bone and Mineral Disorders
Pediatric Kidney Transplantation
Pediatric Transplant Nephrology
Transplant Immunology
Oxalosis
Methylmalonic acidemia
Cystinosis
Foreign Languages Spoken
Program Affiliations
UCSF Biomedical Sciences (BMS) Program
Associate Member, UCSF Liver Center
In the News
Grants and Funding
- Filling a Void of Research (FAVOR) Training for Transplant Surgeons | NIH | 2016-08-01 - 2026-07-31 | Role: Co-Principal Investigator
- Mapping Immune Responses to CMV in Renal Transplant Recipients | NIH | 2017-08-01 - 2022-07-31 | Role: Co-Principal Investigator
- CD40 autoantibody and FSGS recurrence | NIH | 2017-04-01 - 2022-03-31 | Role: Principal Investigator
- Drug Repositioning in Diabetic Nephropathy | NIH | 2016-09-01 - 2020-07-31 | Role: Principal Investigator
- Transplant injury biology and monitoring by urine proteomics | NIH | 2009-07-01 - 2016-08-31 | Role: Principal Investigator
- Urinary Proteome Monitoring for Transplant Injury | NIH | 2010-08-23 - 2015-09-19 | Role: Principal Investigator
- Gene and Cytokine Expression in Tolerance and GVHD | NIH | 2009-09-25 - 2014-08-31 | Role: Co-Principal Investigator
- A Proteomics Research Resource for Integrative Biology | NIH | 2003-09-15 - 2013-06-30 | Role: Co-Investigator
- General Clinical Research Center | NIH | 1978-12-01 - 2011-11-30 | Role: Co-Investigator
- Novel Urinary Proteomic Biomarkers for Acute Renal Transplant Rejection | NIH | 2009-06-01 - 2011-05-31 | Role: Principal Investigator
- Defining Biomarkers in Pediatric Renal Transplantation | NIH | 2004-06-01 - 2009-05-31 | Role: Principal Investigator
Research Narrative
As principal Investigator on numerous multicenter clinical trials, both industry and institutional, Sarwal has developed extensive expertise in the design and execution of clinical studies. While at Stanford, Sarwal conducted the first successful U.S. steroid avoidance trial and the first dosing safety trial for Rituximab in pediatric renal transplantation.
In 2009, Sarwal founded, Organ-i, a Stanford University spin-out to develop and commercialize her pioneering work. Organ-i leveraged 15 years of research and over $20M in NIH grants. The company's goal is to improve the clinical management of transplant patients globally by commericializing non-invasive tests to monitor and predict organ health for transplant recipients.
Sarwal is credited with the introduction of (k-SORT), a Kidney Solid Organ Rejection Test, the company's lead product, as well as a pipeline of molecular assays focused on post-transplant rejection monitoring and allograft tolerance. In June 2014. Immucor, Inc., a global leader in transfusion and transplantation diagnostics, announced the acquisition of Organ-i and retained Sarwal as a scientific advisory role to advance the Organ-i pipeline.
Research Interests
Organ diseases
Transplant immunobiology of rejection and tolerance
Genomics
Proteomics
Antibiomics
Metabolomics
GVHD
Hepatitis B, C and HIV
Research Pathways
Publications
- Gene Expression-based Molecular Scoring of Pancreas Transplant Rejection for a Quantitative Assessment of Rejection Severity and Resistance to Treatment.| | PubMed
- Organ Donation and Transplantation Registries Across the Globe: A Review of the Current State.| | PubMed
- The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts.| | PubMed
- Proteome Analysis for Inflammation Related to Acute and Convalescent Infection.| | PubMed
- Urine trumps the protocol biopsy for subclinical rejection surveillance.| | PubMed
- Transcriptional and spatial profiling of the kidney allograft unravels a central role for FcyRIII+ innate immune cells in rejection.| | PubMed
- Plasma proteome perturbation for CMV DNAemia in kidney transplantation.| | PubMed
- Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.| | PubMed
- Longitudinal serum proteomics analyses identify unique and overlapping host response pathways in Lyme disease and West Nile virus infection.| | PubMed
- Perturbations of the T-cell immune repertoire in kidney transplant rejection.| | PubMed
- Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination.| | PubMed
- The Immune Signatures data resource, a compendium of systems vaccinology datasets.| | PubMed
- Malnutrition and immune cell subsets in children undergoing kidney transplantation.| | PubMed
- A reference tissue atlas for the human kidney.| | PubMed
- Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients.| | PubMed
- Through the Looking Glass: Unraveling the Stage-Shift of Acute Rejection in Renal Allografts.| | PubMed
- Urinary Biomarkers for Kidney Allograft Injury.| | PubMed
- Multiplexed droplet single-cell sequencing (Mux-Seq) of normal and transplant kidney.| | PubMed
- FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease.| | PubMed
- Improving Clinical Trials for Anticomplement Therapies in Complement-Mediated Glomerulopathies: Report of a Scientific Workshop Sponsored by the National Kidney Foundation.| | PubMed
- A large staghorn stone diagnosed and managed in an asymptomatic patient using the "Kidney Injury Test (Kit)" spot urine assay: A case report.| | PubMed
- The Importance of Bringing Transplantation Tolerance to the Clinic.| | PubMed
- A Comprehensive Urine Proteome Database Generated From Patients With Various Renal Conditions and Prostate Cancer.| | PubMed
- Rationale and design of the Kidney Precision Medicine Project.| | PubMed
- Use of the Tissue Common Rejection Module Score in Kidney Transplant as an Objective Measure of Allograft Inflammation.| | PubMed
- Corrigendum: Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.| | PubMed
- Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation.| | PubMed
- Molecular Diversity of Clinically Stable Human Kidney Allografts.| | PubMed
- A multimodal and integrated approach to interrogate human kidney biopsies with rigor and reproducibility: guidelines from the Kidney Precision Medicine Project.| | PubMed
- Single-cell RNA sequencing of Tocilizumab-treated peripheral blood mononuclear cells as an in vitro model of inflammation.| | PubMed
- Impact of Sarcopenia on Simultaneous Pancreas and Kidney Transplantation Outcomes: A Retrospective Observational Cohort Study.| | PubMed
- Near-Single-Cell Proteomics Profiling of the Proximal Tubular and Glomerulus of the Normal Human Kidney.| | PubMed
- Relationship between antithymocyte globulin, T cell phenotypes, and clinical outcomes in pediatric kidney transplantation.| | PubMed
- Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection.| | PubMed
- Clinical and Analytical Validation of a Novel Urine-Based Test for the Detection of Allograft Rejection in Renal Transplant Patients.| | PubMed
- Targeted Urine Metabolomics for Monitoring Renal Allograft Injury and Immunosuppression in Pediatric Patients.| | PubMed
- Avoidance of CNI and steroids using belatacept-Results of the Clinical Trials in Organ Transplantation 16 trial.| | PubMed
- A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.| | PubMed
- Use of biomarkers to improve immunosuppressive drug development and outcomes in renal organ transplantation: A meeting report.| | PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | PubMed
- Non-radiological assessment of kidney stones using the kidney injury test (KIT), a spot urine assay.| | PubMed
- Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.| | PubMed
- Assessment of 19 Genes and Validation of CRM Gene Panel for Quantitative Transcriptional Analysis of Molecular Rejection and Inflammation in Archival Kidney Transplant Biopsies.| | PubMed
- Noninvasive Urinary Monitoring of Progression in IgA Nephropathy.| | PubMed
- A urinary Common Rejection Module (uCRM) score for non-invasive kidney transplant monitoring.| | PubMed
- A Modified Injector and Sample Acquisition Protocol Can Improve Data Quality and Reduce Inter-Instrument Variability of the Helios Mass Cytometer.| | PubMed
- Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing.| | PubMed
- A Novel Multi-Biomarker Assay for Non-Invasive Quantitative Monitoring of Kidney Injury.| | PubMed
- Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets.| | PubMed
- Call for an End to Unethical Transplant Practices: A Concerted Effort by the Transplant Community.| | PubMed
- Cell-Free DNA and CXCL10 Derived from Bronchoalveolar Lavage Predict Lung Transplant Survival.| | PubMed
- Optimizing Detection of Kidney Transplant Injury by Assessment of Donor-Derived Cell-Free DNA via Massively Multiplex PCR.| | PubMed
- The common rejection module in chronic rejection post lung transplantation.| | PubMed
- Urinary Virome Perturbations in Kidney Transplantation.| | PubMed
- Mechanisms and biomarkers of immune quiescence in kidney transplantation.| | PubMed
- Targeted Transcriptional Profiling of Kidney Transplant Biopsies.| | PubMed
- Corrigendum: Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.| | PubMed
- Discovery of Immune Reactive Human Proteins by High-Density Protein Arrays and Customized Validation of Potential Biomarkers by ELISA.| | PubMed
- LC-SRM-Based Targeted Quantification of Urinary Protein Biomarkers.| | PubMed
- Optimization for Peptide Sample Preparation for Urine Peptidomics.| | PubMed
- Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant.| | PubMed
- Protein biomarkers in renal transplantation.| | PubMed
- Expression of Mitochondrial-Encoded Genes in Blood Differentiate Acute Renal Allograft Rejection.| | PubMed
- Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.| | PubMed
- Transplantomics: Toward Precision Medicine in Transplantation Research.| | PubMed
- Retrospective evaluation of the efficacy and safety of belatacept with thymoglobulin induction and maintenance everolimus: A single-center clinical experience.| | PubMed
- A Comprehensive Analysis of the Current Status and Unmet Needs in Kidney Transplantation in Southeast Asia.| | PubMed
- Assessment of Circulating Protein Signatures for Kidney Transplantation in Pediatric Recipients.| | PubMed
- Molecular and Functional Noninvasive Immune Monitoring in the ESCAPE Study for Prediction of Subclinical Renal Allograft Rejection.| | PubMed
- Transplant genetics and genomics.| | PubMed
- Relationship Among Viremia/Viral Infection, Alloimmunity, and Nutritional Parameters in the First Year After Pediatric Kidney Transplantation.| | PubMed
- A combined biomarker and clinical panel for chronic graft versus host disease diagnosis.| | PubMed
- Unraveling the Role of Allo-Antibodies and Transplant Injury.| | PubMed
- Advances in diagnostics for transplant rejection.| | PubMed
- Intragraft Antiviral-Specific Gene Expression as a Distinctive Transcriptional Signature for Studies in Polyomavirus-Associated Nephropathy.| | PubMed
- Self-antigens and rejection: a proteomic analysis.| | PubMed
- Mining the human urine proteome for monitoring renal transplant injury.| | PubMed
- Fingerprints of transplant tolerance suggest opportunities for immunosuppression minimization.| | PubMed
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).| | PubMed
- Non-HLA Antibodies in Clinical Transplantation.| | PubMed
- Circulating CD40 autoantibody and suPAR synergy drives glomerular injury.| | PubMed
- A Computational Gene Expression Score for Predicting Immune Injury in Renal Allografts.| | PubMed
- Computational Models for Transplant Biomarker Discovery.| | PubMed
- Transcriptional Perturbations in Graft Rejection.| | PubMed
- Pediatric Deceased Donation-A Report of the Transplantation Society Meeting in Geneva.| | PubMed
- Antibody-mediated rejection in pediatric kidney transplantation: pathophysiology, diagnosis, and management.| | PubMed
- Tolerance associated gene expression following allogeneic hematopoietic cell transplantation.| | PubMed
- Perturbations in the urinary exosome in transplant rejection.| | PubMed
- Mapping novel immunogenic epitopes in IgA nephropathy.| | PubMed
- Antibody-mediated rejection in young kidney transplant recipients: the dilemma of noncompliance and insufficient immunosuppression.| | PubMed
- A Three-Gene Assay for Monitoring Immune Quiescence in Kidney Transplantation.| | PubMed
- The kSORT assay to detect renal transplant patients at high risk for acute rejection: results of the multicenter AART study.| | PubMed
- Endothelial cell antibodies associated with novel targets and increased rejection.| | PubMed
- A circulating antibody panel for pretransplant prediction of FSGS recurrence after kidney transplantation.| | PubMed
- Inhibition of intracellular clusterin attenuates cell death in nephropathic cystinosis.| | PubMed
- Transcriptional profiling of belatacept and calcineurin inhibitor therapy in renal allograft recipients.| | PubMed
- Quality of life is improved and kidney function preserved in patients with nephropathic cystinosis treated for 2 years with delayed-release cysteamine bitartrate.| | PubMed
- Optimization for peptide sample preparation for urine peptidomics.| | PubMed
- Identification of common blood gene signatures for the diagnosis of renal and cardiac acute allograft rejection.| | PubMed
- The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.| | PubMed
- A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.| | PubMed
- Quality of life after organ transplantation in children.| | PubMed
- Biologic markers of chronic GVHD.| | PubMed
- Moving beyond HLA: a review of nHLA antibodies in organ transplantation.| | PubMed
- A rapid noninvasive assay for the detection of renal transplant injury.| | PubMed
- Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling.| | PubMed
- Identification of gene microarray expression profiles in patients with chronic graft-versus-host disease following allogeneic hematopoietic cell transplantation.| | PubMed
- Immune response profiling identifies autoantibodies specific to Moyamoya patients.| | PubMed
- The clinical impact of humoral immunity in pediatric renal transplantation.| | PubMed
- Significance and suppression of redundant IL17 responses in acute allograft rejection by bioinformatics based drug repositioning of fenofibrate.| | PubMed
- A common blood gene assay predates clinical and histological rejection in kidney and heart allografts.| | PubMed
- Discovery and customized validation of antibody targets by protein arrays and indirect ELISA.| | PubMed
- The pits and pearls in translating operational tolerance biomarkers into clinical practice.| | PubMed
- A peripheral blood diagnostic test for acute rejection in renal transplantation.| | PubMed
- p62/SQSTM1 prominently accumulates in renal proximal tubules in nephropathic cystinosis.| | PubMed
- Stanniocalcin supports the functional adaptation of adult-sized kidneys transplanted into the pediatric recipients.| | PubMed
- Complete steroid avoidance is effective and safe in children with renal transplants: a multicenter randomized trial with three-year follow-up.| | PubMed
- Subclinical inflammation and chronic renal allograft injury in a randomized trial on steroid avoidance in pediatric kidney transplantation.| | PubMed
- Protein and peptide biomarkers in organ transplantation.| | PubMed
- A randomized controlled crossover trial with delayed-release cysteamine bitartrate in nephropathic cystinosis: effectiveness on white blood cell cystine levels and comparison of safety.| | PubMed
- Guidelines for the use and interpretation of assays for monitoring autophagy.| | PubMed
- The bumpy road of genomic medicine in transplantation: lessons from studies on calcineurin inhibitor nephrotoxicity.| | PubMed
- Tolerance and withdrawal of immunosuppressive drugs in patients given kidney and hematopoietic cell transplants.| | PubMed
- A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation.| | PubMed
- Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury.| | PubMed
- Cell-free DNA as a measure of transplant injury.| | PubMed
- Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.| | PubMed
- Recent advances in biomarker discovery in solid organ transplant by proteomics.| | PubMed
- The coin toss of B cells in rejection and tolerance: danger versus defense.| | PubMed
- The dual role of epithelial-to-mesenchymal transition in chronic allograft injury in pediatric renal transplantation.| | PubMed
- Functional proteogenomics--embracing complexity.| | PubMed
- Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.| | PubMed
- Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease.| | PubMed
- Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis.| | PubMed
- Soluble human leukocyte antigen-G in pediatric renal transplantation.| | PubMed
- Applications of translational bioinformatics in transplantation.| | PubMed
- Rituximab treatment for recurrence of nephrotic syndrome in a pediatric patient after renal transplantation for congenital nephrotic syndrome of Finnish type.| | PubMed
- Biomarkers in solid organ transplantation: establishing personalized transplantation medicine.| | PubMed
- Phenotypic evaluation of B-cell subsets after rituximab for treatment of acute renal allograft rejection in pediatric recipients.| | PubMed
- Profiling the proteome in renal transplantation.| | PubMed
- Transplantomics and biomarkers in organ transplantation: a report from the first international conference.| | PubMed
- Organ transplantation after cardiac death.| | PubMed
- Efficacy and safety of thymoglobulin induction as an alternative approach for steroid-free maintenance immunosuppression in pediatric renal transplantation.| | PubMed
- Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease.| | PubMed
- Analysis of clinical variables associated with tolerance in pediatric liver transplant recipients.| | PubMed
- Expression of soluble HLA-G identifies favorable outcomes in liver transplant recipients.| | PubMed
- Differential immunogenicity and clinical relevance of kidney compartment specific antigens after renal transplantation.| | PubMed
- Harnessing the diversity of the human T-cell repertoire: a monitoring tool for transplantation tolerance?| | PubMed
- Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants.| | PubMed
- Abnormal mitochondrial autophagy in nephropathic cystinosis.| | PubMed
- Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosis.| | PubMed
- Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions.| | PubMed
- Molecular diagnostics in transplantation.| | PubMed
- Monitoring calcineurin inhibitor therapy: localizing the moving target.| | PubMed
- Steroid minimization for sirolimus-treated renal transplant recipients.| | PubMed
- Pediatric kidney transplantation.| | PubMed
- Pediatric renal transplantation: an overview and update.| | PubMed
- Cell type-specific gene expression differences in complex tissues.| | PubMed
- Compartmental localization and clinical relevance of MICA antibodies after renal transplantation.| | PubMed
- Integrative urinary peptidomics in renal transplantation identifies biomarkers for acute rejection.| | PubMed
- The yin and yang of B cells in graft rejection and tolerance.| | PubMed
- Caspase-4 may play a role in loss of proximal tubules and renal injury in nephropathic cystinosis.| | PubMed
- Shotgun proteomics identifies proteins specific for acute renal transplant rejection.| | PubMed
- Mitochondrial autophagy promotes cellular injury in nephropathic cystinosis.| | PubMed
- BAFF may modulate the rate of B-cell repopulation after rituximab therapy for acute renal transplant rejection.| | PubMed
- Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients.| | PubMed
- Balancing efficacy and toxicity of kidney transplant immunosuppression.| | PubMed
- Deconvoluting the 'omics' for organ transplantation.| | PubMed
- Promotion of altruistic donation.| | PubMed
- Long-term outcome following pediatric liver transplantation for metabolic disorders.| | PubMed
- Steroid-free immunosuppression in pediatric renal transplantation: rationale for and [corrected] outcomes following conversion to steroid based therapy.| | PubMed
- C3 polymorphisms and outcomes of renal allografts.| | PubMed
- Expression of complement components differs between kidney allografts from living and deceased donors.| | PubMed
- Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patient benefits.| | PubMed
- Standardizing resistive indices in healthy pediatric transplant recipients of adult-sized kidneys.| | PubMed
- Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures.| | PubMed
- Calcineurin inhibitor nephrotoxicity.| | PubMed
- Using gene arrays in diagnosis of rejection.| | PubMed
- Interpreting the proteome and peptidome in transplantation.| | PubMed
- Combined liver-kidney transplantation in children: indications and outcome.| | PubMed
- A critical look at the immunologically favorable adult-sized kidney transplant in small children.| | PubMed
- Extended daclizumab monotherapy for rejection-free survival in non-adherent adolescent recipients of renal allografts.| | PubMed
- Out with the old, in with the new: immunosuppression minimization in children.| | PubMed
- A randomized, prospective trial of rituximab for acute rejection in pediatric renal transplantation.| | PubMed
- Microarrays: monitoring for transplant tolerance and mechanistic insights.| | PubMed
- The proteogenomic path towards biomarker discovery.| | PubMed
- Renal transplantation in children with thrombosis of the inferior vena cava requires careful assessment and planning.| | PubMed
- Patient selection critical for calcineurin inhibitor withdrawal in pediatric kidney transplantation.| | PubMed
- "To B or not to B?" B-cells and graft rejection.| | PubMed
- In praise of arrays.| | PubMed
- Characterization of intra-graft B cells during renal allograft rejection.| | PubMed
- Optimizing protein recovery for urinary proteomics, a tool to monitor renal transplantation.| | PubMed
- Maturation of dose-corrected tacrolimus predose trough levels in pediatric kidney allograft recipients.| | PubMed
- Looking into the crystal chip: can microarrays predict graft function?| | PubMed
- Liposomal amphotericin B associated with severe hyperphosphatemia.| | PubMed
- Potential influence of tacrolimus and steroid avoidance on early graft function in pediatric renal transplantation.| | PubMed
- Interference of globin genes with biomarker discovery for allograft rejection in peripheral blood samples.| | PubMed
- Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance.| | PubMed
- Transplant reno-vascular stenoses associated with early erythropoietin use.| | PubMed
- The evolution of nonimmune histological injury and its clinical relevance in adult-sized kidney grafts in pediatric recipients.| | PubMed
- Immunosuppression minimization in pediatric transplantation.| | PubMed
- Optimizing outcomes for neonatal ARPKD.| | PubMed
- Sirolimus is not always responsible for new-onset proteinuria after conversion for chronic allograft nephropathy.| | PubMed
- Subclinical cytomegalovirus and Epstein-Barr virus viremia are associated with adverse outcomes in pediatric renal transplantation.| | PubMed
- Proteinuria in pediatric renal transplant recipients during the first 60 post-transplant days.| | PubMed
- Designer genes: Filling the gap in transplantation.| | PubMed
- Successful renal transplantation in high-risk small children with a completely thrombosed inferior vena cava.| | PubMed
- A novel, semiquantitative, clinically correlated calcineurin inhibitor toxicity score for renal allograft biopsies.| | PubMed
- Microarrays: a monitoring tool for transplant patients?| | PubMed
- Chipping into the human genome: novel insights for transplantation.| | PubMed
- Option of pre-emptive nephrectomy and renal transplantation for Bartter's syndrome.| | PubMed
- Three cases of suspected antibody-mediated rejection.| | PubMed
- Transcriptional analysis of the molecular basis of human kidney aging using cDNA microarray profiling.| | PubMed
- Steroid elimination is coming of age.| | PubMed
- Mycophenolate mofetil in pediatric renal transplantation.| | PubMed
- Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival.| | PubMed
- Corticosteroid avoidance in pediatric renal transplantation.| | PubMed
- Gastrointestinal leukocytoclastic vasculitis: an adverse effect of sirolimus.| | PubMed
- Vulnerability of small pediatric recipients to laparoscopic living donor kidneys.| | PubMed
- First NIH/Office of Rare Diseases Conference on Cystinosis: past, present, and future.| | PubMed
- Management of methylmalonic acidaemia by combined liver-kidney transplantation.| | PubMed
- Correlation between gene expression and morphological alterations in baboon carotid after balloon dilatation injury.| | PubMed
- Microangiopathy of brain, retina, and inner ear (Susac's syndrome) in an adolescent female presenting as acute disseminated encephalomyelitis.| | PubMed
- Arraying the orchestration of allograft pathology.| | PubMed
- Corticosteroid avoidance in pediatric renal transplantation: can it be achieved?| | PubMed
- Microarrays: interrogating the transplant transcriptosome.| | PubMed
- Noncirrhotic portal hypertension in association with juvenile nephropathic cystinosis: case presentation and review of the literature.| | PubMed
- Postdialysis albumin: a better nutrition marker in pediatric hemodialysis patients?| | PubMed
- A typology of non-adherence in pediatric renal transplant recipients.| | PubMed
- One hundred percent patient and kidney allograft survival with simultaneous liver and kidney transplantation in infants with primary hyperoxaluria: a single-center experience.| | PubMed
- Continued superior outcomes with modification and lengthened follow-up of a steroid-avoidance pilot with extended daclizumab induction in pediatric renal transplantation.| | PubMed
- Applications of microarrays to renal transplantation: progress and possibilities.| | PubMed
- Safety and risk stratification of percutaneous biopsies of adult-sized renal allografts in infant and older pediatric recipients.| | PubMed
- Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling.| | PubMed
- Chronic rejection: prospects for therapeutic intervention in fibroproliferative vascular disease.| | PubMed
- Microarrays: new tools for transplantation research.| | PubMed
- Increased expression of cytotoxic effector molecules: different interpretations for steroid-based and steroid-free immunosuppression.| | PubMed
- Molecular profiling of anemia in acute renal allograft rejection using DNA microarrays.| | PubMed
- Unexpectedly high prevalence of posttransplant anemia in pediatric and young adult renal transplant recipients.| | PubMed
- Limited surgical interventions in children with posterior urethral valves can lead to better outcomes following renal transplantation.| | PubMed
- Rational drug design: making drugs that make a difference.| | PubMed
- Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation.| | PubMed
- Visual loss caused by pseudotumor cerebri in an infant on peritoneal dialysis.| | PubMed
- Genomic analysis of renal allograft dysfunction using cDNA microarrays.| | PubMed
- Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation.| | PubMed
- Adult-size kidneys without acute tubular necrosis provide exceedingly superior long-term graft outcomes for infants and small children: a single center and UNOS analysis. United Network for Organ Sharing.| | PubMed
- Sodium ferric gluconate therapy in renal transplant and renal failure patients.| | PubMed
- A 100% 2-year graft survival can be attained in high-risk 15-kg or smaller infant recipients of kidney allografts.| | PubMed
- Renal perfusion in infant recipients of adult-sized kidneys is a critical risk factor.| | PubMed
- Pulmonary capillary leak syndrome with intravenous cyclosporin A in pediatric renal transplantation.| | PubMed
- A new, unique and simple method for ureteral implantation in kidney recipients with small, defunctionalized bladders.| | PubMed
- Transplantation of adult-sized kidneys into infants induces major blood flow changes.| | PubMed
- Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow.| | PubMed
- G protein alpha subunit multigene family in the Japanese puffer fish Fugu rubripes: PCR from a compact vertebrate genome.| | PubMed