University of California San Francisco

Tippi MacKenzie large headshot
Tippi
MacKenzie
MD

Professor of Surgery
Benioff UCSF Professor of Children’s Health 
Director, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF 
Co-Director, Center for Maternal-Fetal Precision Medicine 
John G. Bowes Distinguished Professor of Stem Cell and Tissue Biology

Address

35 Medical Center Way, #001
San Francisco, CA 94143
United States

Email: [email protected]
Phone: 415-476-2479
Fax: 415-476-2314

Biography

Tippi MacKenzie is a pediatric and fetal surgeon who is focused on developing better ways to diagnose and treat genetic diseases before birth. She leads a translational research lab examining the unique biology between the mother and her fetus, with the idea that pregnancy complications such as preterm labor arise from a breakdown in maternal-fetal tolerance. At present, the MacKenzie group is focused on preterm labor and fetal therapies including stem cell transplantation, enzyme replacement therapy, and gene therapy.

Videos

Education

Institution Degree Dept or School End Date
Children's Hospital of Philadelphia Fellow Pediatric Surgery 2007
Brigham and Women's Hospital Chief Resident Surgery 2005
Brigham and Women's Hospital Residency Surgery 2004
Children's Hospital of Philadelphia Postdoctoral Studies Fetal Therapy 2002
Stanford University M.D. Medicine 1997

Board Certifications

  • American Board of Surgery, 2006

Clinical Expertise

Advanced Laparoscopy
Birth Defects
Endocrine and Biliary Surgery
Fetal Surgery
Pediatric Surgery

Clinical Trials

  1. International Registry of Patients With Alpha Thalassemia (NCT04872179)
    Related Conditions: Alpha Thalassemia, Alpha Thalassemia Major, Beta Thalassemia| Start Date: | End Date:
  2. In Utero Enzyme Replacement Therapy for Lysosomal Storage Diseases (NCT04532047)
    Related Conditions: Mucopolysaccharidosis, Mucopolysaccharidosis Type I, Hunter Syndrome, Mucopolysaccharidosis Type Iva, Mucopolysaccharidosis Type VI, Mucopolysaccharidosis Type VII, Gaucher Disease, Pompe Disease, Wolman Disease| Start Date: | End Date:
  3. In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM) (NCT02986698)
    Related Conditions: Alpha Thalassemia, Alpha Thalassemia Major, Hemoglobinopathy, Anemia, Hydrops Fetalis, Bone Marrow Transplant, Hematopoietic Cell Transplantation, Stem Cell Transplant, Beta Thalassemia| Start Date: | End Date:

Program Affiliations

  • Fetal Treatment Center
  • Biomedical Sciences Program
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research
  • Center for Maternal-Fetal Precision Medicine

Grants and Funding

  • Phase 1 Study of In Utero Enzyme Replacement Therapy for the Treatment of Lysosomal Storage Diseases | NIH/NICHHD | 2022-09-20 - 2027-04-30 | Role: Principal Investigator
  • Developing gene therapy strategies to treat alpha thalassemia | NIH/NHLBI | 2022-01-01 - 2025-12-31 | Role: Principal Investigator
  • Autoimmune Regulator gene (Aire)-mediated tolerance to pregnancy-associated self-antigens | NIH | 2019-08-21 - 2024-07-31 | Role: Principal Investigator
  • In utero hematopoietic stem cell transplantation for the treatment of fetuses with alpha thalassemia major (phase I clinical trial) | California Institute for Regenerative Medicine (CIRM) | 2017-08-01 - 2022-07-31 | Role: Principal Investigator
  • A precision medicine approach to detect dysbiosis and immune activation in preterm labor | Burroughs Wellcome Fund Preterm Labor Initiative | 2017-07-01 - 2021-06-30 | Role: Principal Investigator
  • T cell activation and the breakdown of maternal-fetal tolerance in preterm labor | NIH | 2015-06-15 - 2021-05-31 | Role: Principal Investigator

Research Narrative

Dr. MacKenzie has an active laboratory and is a member of the Biomedical Sciences Program and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research. Her research focus is on mechanisms of tolerance induction following in utero stem cell transplantation  and the pathophysiology of prenatally diagnosed diseases, such as congenital diaphragmatic hernia and gastroschisis, to identify biomarkers that predict prognosis and molecular pathways that may be targets for prenatal intervention.

Research Interests

In-Utero Stem Cell Transplantation

Research Pathways

Basic Biomedical & Translational Research
Clinical Discovery & Health Services Research

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 104
  1. In utero hematopoietic stem cell transplantation for Fanconi anemia.
    Swartzrock L, Dib C, Denis M, Willner H, Ho K, Haslett E, Han J, Pan W, Byrne-Steele M, Brown B, Krampf MR, Girsen A, Blumenfeld YJ, El-Sayed YY, Roncarolo MG, MacKenzie TC, Czechowicz AD| | PubMed
  2. The Conundrum of Mechanics Versus Genetics in Congenital Hydrocephalus and Its Implications for Fetal Therapy Approaches: A Scoping Review.
    Herzeg A, Borges B, Diafos LN, Gupta N, MacKenzie TC, Sanders SJ| | PubMed
  3. Dual α-globin and truncated EPO receptor knockin restores hemoglobin production in α-thalassemia-derived red blood cells.
    Chu SN, Soupene E, Wienert B, Yin H, Sharma D, McCreary T, Jia K, Homma S, Hampton JP, Gardner JM, Conklin BR, MacKenzie TC, Porteus MH, Cromer MK| | PubMed
  4. Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.
    Borges B, Varthaliti A, Schwab M, Clarke MT, Pivetti C, Gupta N, Cadwell CR, Guibinga G, Phillips S, Del Rio T, Ozsolak F, Imai-Leonard D, Kong L, Laird DJ, Herzeg A, Sumner CJ, MacKenzie TC| | PubMed
  5. Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman syndrome phenotype in mice.
    Clarke MT, Remesal L, Lentz L, Tan DJ, Young D, Thapa S, Namuduri SR, Borges B, Kirn G, Valencia J, Lopez ME, Lui JH, Shiow LR, Dindot S, Villeda S, Sanders SJ, MacKenzie TC| | PubMed
  6. Intrauterine enzyme replacement therapies for lysosomal storage disorders: Current developments and promising future prospects.
    Herzeg A, Borges B, Lianoglou BR, Gonzalez-Velez J, Canepa E, Munar D, Young SP, Bali D, Gelb MH, Chakraborty P, Kishnani PS, Harmatz P, Cohen JL, MacKenzie TC| | PubMed
  7. Systematic evaluation of genome sequencing for the diagnostic assessment of autism spectrum disorder and fetal structural anomalies.
    Lowther C, Valkanas E, Giordano JL, Wang HZ, Currall BB, O'Keefe K, Pierce-Hoffman E, Kurtas NE, Whelan CW, Hao SP, Weisburd B, Jalili V, Fu J, Wong I, Collins RL, Zhao X, Austin-Tse CA, Evangelista E, Lemire G, Aggarwal VS, Lucente D, Gauthier LD, Tolonen C, Sahakian N, Stevens C, An JY, Dong S, Norton ME, MacKenzie TC, Devlin B, Gilmore K, Powell BC, Brandt A, Vetrini F, DiVito M, Sanders SJ, MacArthur DG, Hodge JC, O'Donnell-Luria A, Rehm HL, Vora NL, Levy B, Brand H, Wapner RJ, Talkowski ME| | PubMed
  8. Are we prepared to deliver gene-targeted therapies for rare diseases?
    Yu TW, Kingsmore SF, Green RC, MacKenzie T, Wasserstein M, Caggana M, Gold NB, Kennedy A, Kishnani PS, Might M, Brooks PJ, Morris JA, Parisi MA, Urv TK| | PubMed
  9. The impact of in utero transfusions on perinatal outcomes in patients with alpha thalassemia major: the UCSF registry.
    Schwab ME, Lianoglou BR, Gano D, Gonzalez Velez J, Allen IE, Arvon R, Baschat A, Bianchi DW, Bitanga M, Bourguignon A, Brown RN, Chen B, Chien M, Davis-Nelson S, de Laat MWM, Ekwattanakit S, Gollin Y, Hirata G, Jelin A, Jolley J, Meyer P, Miller J, Norton ME, Ogasawara KK, Panchalee T, Schindewolf E, Shaw SW, Stumbaugh T, Thompson AA, Towner D, Tsai PS, Viprakasit V, Volanakis E, Zhang L, Vichinsky E, MacKenzie TC| | PubMed
  10. In Utero Enzyme-Replacement Therapy for Infantile-Onset Pompe's Disease.
    Cohen JL, Chakraborty P, Fung-Kee-Fung K, Schwab ME, Bali D, Young SP, Gelb MH, Khaledi H, DiBattista A, Smallshaw S, Moretti F, Wong D, Lacroix C, El Demellawy D, Strickland KC, Lougheed J, Moon-Grady A, Lianoglou BR, Harmatz P, Kishnani PS, MacKenzie TC| | PubMed
  11. Investigating attitudes toward prenatal diagnosis and fetal therapy for spinal muscular atrophy.
    Schwab ME, Shao S, Zhang L, Lianoglou B, Belter L, Jarecki J, Schroth M, Sumner CJ, MacKenzie T| | PubMed
  12. Prenatal Somatic Cell Gene Therapies: Charting a Path Toward Clinical Applications (Proceedings of the CERSI-FDA Meeting).
    Herzeg A, Almeida-Porada G, Charo RA, David AL, Gonzalez-Velez J, Gupta N, Lapteva L, Lianoglou B, Peranteau W, Porada C, Sanders SJ, Sparks TN, Stitelman DH, Struble E, Sumner CJ, MacKenzie TC| | PubMed
  13. Thymic and extrathymic Aire-expressing cells in maternal-fetal tolerance.
    Sun IH, Gillis-Buck E, Mackenzie TC, Gardner JM| | PubMed
  14. Fetal therapies and trials for lysosomal storage diseases: a survey of attitudes of parents and patients.
    Schwab ME, Brown JEH, Lianoglou B, Jin C, Conroy PC, Gallagher RC, Harmatz P, MacKenzie TC| | PubMed
  15. Consensus statement for the perinatal management of patients with α thalassemia major.
    MacKenzie TC, Amid A, Angastiniotis M, Butler C, Gilbert S, Gonzalez J, Keller RL, Kharbanda S, Kirby-Allen M, Koenig BA, Kyono W, Lal A, Lianoglou BR, Norton ME, Ogasawara KK, Panchalee T, Rosner M, Schwab M, Thompson A, Waye JS, Vichinsky E| | PubMed
  16. Advances in the management of α-thalassemia major: reasons to be optimistic.
    Horvei P, MacKenzie T, Kharbanda S| | PubMed
  17. Prenatal Gene Therapy.
    Schwab ME, MacKenzie TC| | PubMed
  18. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants.
    Le BL, Sper R, Nielsen SCA, Pineda S, Nguyen QH, Lee JY, Boyd SD, MacKenzie TC, Sirota M| | PubMed
  19. Exome sequencing of fetuses with congenital diaphragmatic hernia supports a causal role for NR2F2, PTPN11, and WT1 variants.
    Schwab ME, Dong S, Lianoglou BR, Aguilar Lucero AF, Schwartz GB, Norton ME, MacKenzie TC, Sanders SJ| | PubMed
  20. Extrathymic Aire-expressing cells support maternal-fetal tolerance.
    Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC| | PubMed
  21. Forever Connected: The Lifelong Biological Consequences of Fetomaternal and Maternofetal Microchimerism.
    Bianchi DW, Khosrotehrani K, Way SS, MacKenzie TC, Bajema I, O'Donoghue K| | PubMed
  22. Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement.
    Sagar R, Almeida-Porada G, Blakemore K, Chan JKY, Choolani M, Götherström C, Jaulent A, MacKenzie TC, Mattar C, Porada CD, Peranteau WH, Schneider H, Shaw SW, Waddington SN, Westgren M, David AL| | PubMed
  23. Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis.
    Sparks TN, Lianoglou BR, Adami RR, Pluym ID, Holliman K, Duffy J, Downum SL, Patel S, Faubel A, Boe NM, Field NT, Murphy A, Laurent LC, Jolley J, Uy C, Slavotinek AM, Devine P, Hodoglugil U, Van Ziffle J, Sanders SJ, MacKenzie TC, Norton ME, University of California Fetal–Maternal Consortium, University of California, San Francisco Center for Maternal–Fetal Precision Medicine| | PubMed
  24. Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing.
    Witt RG, Blair L, Frascoli M, Rosen MJ, Nguyen QH, Bercovici S, Zompi S, Romero R, Mackenzie TC| | PubMed
  25. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII.
    Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC| | PubMed
  26. CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
    Halkias J, Rackaityte E, Hillman SL, Aran D, Mendoza VF, Marshall LR, MacKenzie TC, Burt TD| | PubMed
  27. In Utero Gene Therapy Consensus Statement from the IFeTIS.
    Almeida-Porada G, Waddington SN, Chan JKY, Peranteau WH, MacKenzie T, Porada CD| | PubMed
  28. Evaluation of Clinical Outcomes of Sutureless vs Sutured Closure Techniques in Gastroschisis Repair.
    Witt RG, Zobel M, Padilla B, Lee H, MacKenzie TC, Vu L| | PubMed
  29. Depletion of murine fetal hematopoietic stem cells with c-Kit receptor and CD47 blockade improves neonatal engraftment.
    Witt RG, Wang B, Nguyen QH, Eikani C, Mattis AN, MacKenzie TC| | PubMed
  30. Large Differences in Small RNA Composition Between Human Biofluids.
    Godoy PM, Bhakta NR, Barczak AJ, Cakmak H, Fisher S, MacKenzie TC, Patel T, Price RW, Smith JF, Woodruff PG, Erle DJ| | PubMed
  31. Future AAVenues for In Utero Gene Therapy.
    MacKenzie TC| | PubMed
  32. Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth.
    Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M| | PubMed
  33. Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α.
    Frascoli M, Coniglio L, Witt R, Jeanty C, Fleck-Derderian S, Myers DE, Lee TH, Keating S, Busch MP, Norris PJ, Tang Q, Cruz G, Barcellos LF, Gomez-Lopez N, Romero R, MacKenzie TC| | PubMed
  34. Systemic multilineage engraftment in mice after in utero transplantation with human hematopoietic stem cells.
    Witt RG, Kreger EM, Buckman LB, Moradi PW, Ho PT, Derderian SC, Tsai P, Baker C, Schramm N, Cleary R, Garcia JV, MacKenzie TC| | PubMed
  35. Esophagoesophagopexy technique for assisted fistulization of esophageal atresia.
    Chumfong I, Lee H, Padilla BE, MacKenzie TC, Vu LT| | PubMed
  36. Non-Immune Hydrops Fetalis: Do Placentomegaly and Polyhydramnios Matter?
    Berger VK, Sparks TN, Jelin AC, Derderian C, Jeanty C, Gosnell K, Mackenzie T, Gonzalez JM| | PubMed
  37. Sacrococcygeal teratoma: late recurrence warrants long-term surveillance.
    Padilla BE, Vu L, Lee H, MacKenzie T, Bratton B, O'Day M, Derderian S| | PubMed
  38. Fetal stem cell and gene therapy.
    Witt R, MacKenzie TC, Peranteau WH| | PubMed
  39. Epidemiology of Live Born Infants with Nonimmune Hydrops Fetalis-Insights from a Population-Based Dataset.
    Steurer MA, Peyvandi S, Baer RJ, MacKenzie T, Li BC, Norton ME, Jelliffe-Pawlowski LL, Moon-Grady AJ| | PubMed
  40. Favorable outcomes after in utero transfusion in fetuses with alpha thalassemia major: a case series and review of the literature.
    Kreger EM, Singer ST, Witt RG, Sweeters N, Lianoglou B, Lal A, Mackenzie TC, Vichinsky E| | PubMed
  41. A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells.
    Beaudin AE, Boyer SW, Perez-Cunningham J, Hernandez GE, Derderian SC, Jujjavarapu C, Aaserude E, MacKenzie T, Forsberg EC| | PubMed
  42. Magnetic resonance imaging of Müllerian duct anomalies in children.
    Li Y, Phelps A, Zapala MA, MacKenzie JD, MacKenzie TC, Courtier J| | PubMed
  43. Heightened Immune Activation in Fetuses with Gastroschisis May Be Blocked by Targeting IL-5.
    Frascoli M, Jeanty C, Fleck S, Moradi PW, Keating S, Mattis AN, Tang Q, MacKenzie TC| | PubMed
  44. Mass Effect Alone May Not Explain Pulmonary Vascular Pathology in Severe Congenital Diaphragmatic Hernia.
    Derderian SC, Jayme CM, Cheng LS, Keller RL, Moon-Grady AJ, MacKenzie TC| | PubMed
  45. Fetal Surgical conditions and the unraveling of maternal-fetal tolerance.
    MacKenzie TC| | PubMed
  46. A booster shot to cure hemoglobinopathies.
    Walters MC, MacKenzie TC| | PubMed
  47. Maternal factors associated with the occurrence of gastroschisis.
    Baer RJ, Chambers CD, Jones KL, Shew SB, MacKenzie TC, Shaw GM, Jelliffe-Pawlowski LL| | PubMed
  48. Increased maternal T cell microchimerism in the allogeneic fetus during LPS-induced preterm labor in mice.
    Wegorzewska M, Le T, Tang Q, MacKenzie TC| | PubMed
  49. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy.
    MacKenzie TC, David AL, Flake AW, Almeida-Porada G| | PubMed
  50. In utero hematopoietic cell transplantation for hemoglobinopathies.
    Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC| | PubMed
  51. Placental drug delivery for treatment of congenital hematopoietic disorders.
    Derderian SC, Moradi PW, MacKenzie TC| | PubMed
  52. The many faces of hydrops.
    Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC| | PubMed
  53. Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia.
    Jeanty C, Kunisaki SM, MacKenzie TC| | PubMed
  54. Favorable outcomes in high-risk congenital pulmonary airway malformations treated with multiple courses of maternal betamethasone.
    Derderian SC, Coleman AM, Jeanty C, Lim FY, Shaaban AM, Farrell JA, Hirose S, MacKenzie TC, Lee H| | PubMed
  55. Maternal-fetal cellular trafficking: clinical implications and consequences.
    Jeanty C, Derderian SC, Mackenzie TC| | PubMed
  56. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
    Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC| | PubMed
  57. Memory regulatory T cells reside in human skin.
    Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD| | PubMed
  58. Outcomes of fetal intervention for primary hydrothorax.
    Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC| | PubMed
  59. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise.
    Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC| | PubMed
  60. Anal duplication in a one-year-old girl.
    Cheng LS, Courtier J, MacKenzie TC| | PubMed
  61. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia.
    Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC| | PubMed
  62. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice.
    Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC| | PubMed
  63. Clinical implications of maternal-fetal cellular trafficking.
    Nijagal A, MacKenzie TC| | PubMed
  64. Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review.
    Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D| | PubMed
  65. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin.
    Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC| | PubMed
  66. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases.
    Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC| | PubMed
  67. Increased maternal microchimerism after open fetal surgery.
    Saadai P, MacKenzie TC| | PubMed
  68. Alterations in maternal-fetal cellular trafficking after fetal surgery.
    Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC| | PubMed
  69. Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome.
    Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H| | PubMed
  70. In utero hematopoietic cell transplantation for the treatment of congenital anomalies.
    Nijagal A, Flake AW, MacKenzie TC| | PubMed
  71. Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance.
    Nijagal A, Fleck S, MacKenzie TC| | PubMed
  72. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia.
    Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC| | PubMed
  73. Pancreatic mesenchyme regulates epithelial organogenesis throughout development.
    Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M| | PubMed
  74. The maternal immune response inhibits the success of in utero hematopoietic cell transplantation.
    Nijagal A, Wegorzewska M, Le T, Tang Q, Mackenzie TC| | PubMed
  75. A mouse model of in utero transplantation.
    Nijagal A, Le T, Wegorzewska M, Mackenzie TC| | PubMed
  76. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
    Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC| | PubMed
  77. Image of the month--quiz case. Gastric duplication cyst.
    Zaid HB, Rhee SJ, Hirose S, Mackenzie TC| | PubMed
  78. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution.
    Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K| | PubMed
  79. Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice.
    Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA| | PubMed
  80. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery.
    Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS| | PubMed
  81. Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors.
    MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW| | PubMed
  82. Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice.
    Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW| | PubMed
  83. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes.
    MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S, Wilson JM, Verma IM, Flake AW| | PubMed
  84. The ex-utero intrapartum treatment.
    MacKenzie TC, Crombleholme TM, Flake AW| | PubMed
  85. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice.
    Mackenzie TC, Shaaban AF, Radu A, Flake AW| | PubMed
  86. The natural history of prenatally diagnosed conjoined twins.
    Mackenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS| | PubMed
  87. Human mesenchymal stem cells: insights from a surrogate in vivo assay system.
    MacKenzie TC, Flake AW| | PubMed
  88. Risk factors for intermediate-term survival after coronary artery bypass grafting.
    Gardner SC, Grunwald GK, Rumsfeld JS, Mackenzie T, Gao D, Perlin JB, McDonald G, Shroyer AL| | PubMed
  89. Large-volume paracentesis in the management of ascites in children.
    Kramer RE, Sokol RJ, Yerushalmi B, Liu E, MacKenzie T, Hoffenberg EJ, Narkewicz MR| | PubMed
  90. Survival after first esophageal variceal hemorrhage in patients with biliary atresia.
    Miga D, Sokol RJ, Mackenzie T, Narkewicz MR, Smith D, Karrer FM| | PubMed
  91. The management of prenatally diagnosed choledochal cysts.
    Mackenzie TC, Howell LJ, Flake AW, Adzick NS| | PubMed
  92. A fetal lung lesion consisting of bronchogenic cyst, bronchopulmonary sequestration, and congenital cystic adenomatoid malformation: the missing link?
    MacKenzie TC, Guttenberg ME, Nisenbaum HL, Johnson MP, Adzick NS| | PubMed
  93. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep.
    Mackenzie TC, Flake AW| | PubMed
  94. Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States.
    Redondo MJ, Yu L, Hawa M, Mackenzie T, Pyke DA, Eisenbarth GS, Leslie RD| | PubMed
  95. The impact of the diabetes control and complications trial and humalog insulin on glycohemoglobin levels and severe hypoglycemia in type 1 diabetes.
    Chase HP, Lockspeiser T, Peery B, Shepherd M, MacKenzie T, Anderson J, Garg SK| | PubMed
  96. Multilineage differentiation of human MSC after in utero transplantation.
    Mackenzie TC, Flake AW| | PubMed
  97. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep.
    Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW| | PubMed
  98. Response to treatment as a predictor of longterm outcome in patients with lupus nephritis.
    Fraenkel L, MacKenzie T, Joseph L, Kashgarian M, Hayslett JP, Esdaile JM| | PubMed
  99. The time-dependence of long-term prediction in lupus nephritis.
    Esdaile JM, Abrahamowicz M, MacKenzie T, Hayslett JP, Kashgarian M| | PubMed
  100. Can experienced clinicians predict the outcome of lupus nephritis?
    Esdaile JM, Mackenzie T, Barré P, Danoff D, Osterland CK, Somerville P, Quintal H, Kashgarian M, Suissa S| | PubMed
  101. Cerebrovascular deaths before and after the appearance of oral contraceptives.
    Lidegaard O| | PubMed
  102. Systemic and renal hemodynamic consequences of manipulation of serum calcium and/or parathyroid hormone in the intact conscious mongrel dog.
    Zawada ET, Johnson M, McClung D, TerWee J, MacKenzie T| | PubMed
  103. Hemoglobin A1 in renal transplant recipients.
    Zawada ET, Johnson M, Mackenzie T, Sica DA, Muakkassa W, Green SJ, Goldman M| | PubMed
  104. Effect of clonidine therapy on renal hemodynamics in renal transplant hypertension.
    Green S, Zawada ET, Muakkassa W, Johnson M, Mackenzie T, McClanahan M, Graybill A, Goldman M| | PubMed